Macular holes and foveal cyst
an OCT scan showing a macula hole enlarge
A macular hole is a hole in the very centre of the retina, in the fovea. (The fovea is the centre of the macular area.) Vision is reduced. A patient with small new hole may read a word and may notice a few letters missing, and have about 6/12 vision. (animation
- Surgery is often helpful, although the operation is quite a major. An epiretinal membrane peel is needed to repair a macula hole.
- Without surgery >90% holes (bigger than 200µ) may progress and ultimately reduce vision to ~6/60. Therefore surgery is recommended for most well patients, if the sight is still good.
- 100µ holes ...80% get bigger.
- high myopes Eye 15
- 2 types..tractional and degenerative AJO 16
The condition occurs as people get older. We do not know the exact cause, but It develops as the vitreous gel shrinks. See posterior vitreous detachment PVD.
A hole with good sight may progress. So a patient with 6/24 vision , for instance, may generally benefit from surgery. Expert advice is needed for individual patients.
Macular holes often follow the condition vitreo-macular traction (VMT). It is probably an advanced form of VMT.
It is 'normal' for the vitreous to detach from the back of the retina as we get older. But in this condition, the vitreous is abnormally 'stuck' to the central part of the retina, and pulls it a little. As it pulls he retina it creates a tiny hole.
A foveal cyst like the one below may be is an early stage of a hole. The fovea is the centre of the macula, and this may develop a cyst as below. Some cysts are due to macular oedema/inflammation as in diabetes, but others are 'early' macular holes as the one shown here. Unless a hole does develop, surgery is not usually needed. Causes are the same as macular hole as below.
a foveal cyst, sometimes develops into a macular hole
This is not a hole, but a RPE defect, that may be due to an eclipse burn. It may cause a tiny amount of distortion enlarge (I am not sure of the exact term for this appearance).
This is a half-thickness hole in the fovea. It causes distortion of central vision, or missing letters in word. An example would be missing the 'g' in 'age'. The cause in this cause is an epiretinal membrane BJO 2013. 80% of lamellar holes remain stable, 20% do deteriorate...surgery can be helpful in this group.
a lamellar macula hole due to an epiretinal membrane enlarge
- lamellar hole with and without erm Retina15
- erm Retina15
- lamellar holes are either degenerative (no surgery) or part of an ERM (epiretinal membrane: surgery may help some patients)
If there is no remaining foveal tissue, surgery will not improve sight.
Can be repaired. Eye 17
- Incidence is 1/10000 year.
- Surgery helps stage 2-4, (Films study: Ilm peel best)
- Larger holes are treated with vitrectomy, similarly to ERM peel.
- If other eye has VMT, this is likely to progress into a hole (42%).
- Ocriplasmin may help <400µ NEJM 12 see. Only 16% macula holes are <400µ BJO 16
- After surgery sight improves for 6 months Retina 16.
- Vertical traction from the vitreous causes more of a problem Eye 17.
There is a new classification of macula hole. Stage 1-2 may settle them selves, stage 3-4 need surgery to improve symptoms.
- Stage 1a..............foveal depression lost, yellow spot, a little VMT, small hole< 200µ
- Stage 1b...............more VMT
- Stage 2 ................VMT like a drawbridge, can get complete recovery
- Stage 3..................bigger hole, > 400µ, <1500
- Stage 4..................hole>1500µ,
- Stage 4..................same, with operculum
- RPE protrusion indicate worse prognosis Retina 17
A patient, Age 67, female