Good Hope, Heartlands, and Solihull Eye Clinics

Wet age related macular degeneration (ARMD)

David Kinshuck

ARMD introduction

ARMD is an aging change or wearing out of the central retina. It causes loss of central vision. This makes reading and driving difficult. Later, if it gets more severe, it becomes difficult seeing faces, crossing roads, and cooking. The peripheral or side vision always remains, so even if the central vision is poor, it is always possible to see and get round the house and see to the side.

Dry ARMD is usually a progressive condition. Invisible early changes occur, with drusen , pigmentary changes, and slight thinning of the retina    Later, the dry changes may progress, usually slowly, to cause geographic atrophy and more thinning of central retina. These are all termed part of 'dry' ARMD. There is no tretment for dry ARMD.

A secondary change may then develop in some people, as the body tries to 'heal' the changes. Blood vessels may start to grow in the dmaged centre of the retina in the macula area. The blood vessel growth causes leakage and scarring, and is termed 'wet' ARMD. These wet changes can be slowed down with anti-VEGF eye injections (wet ARMD page).

This page summarises our current knowledge. Age-related macular degeneration is explained in more detail on other web-sites, such as the RNIB. An excellent animation:


Contributing factors: aging, genes, diet, smoking, etc

Age-related macular degeneration (ARMD) is one of the commonest causes of poor sight in developed countries. Whilst the causes are different in different people, certain factors may contribute. The main factor is age. 

"By age 85, 57.4% of [people have] AMD. Age, smoking, plasma HDL cholesterol, BMI, and female sex are associated with AMD. Elevated HDL cholesterol is associated with GA development."  .Oph 14


age Age is the main factor.
smoking Contributes 32% overall, even passive smoking. BJO 17.
'Just one cigarette a day seriously elevates cardiovascular risk ' BMJ18, so it is best to stop completely. Ophth 20
diet related up to ~30%; a high cholesterol from an unhealthy diet or genes Klein (2010); Toothbrushing helps. (tooth decay promotes conditions such as rheumatoid arthritissummary  BJO16  
blood pressure High blood pressure damages the is 140 systolic in clinic, 10 lower for diabetes. 10 lower at home. 120 at home for diabetes at home. Best below 120    2 medications often required.

reduces progression to neovascular ARMD by 70%     AJO17

genes ~50% is directly due to the genes we inherit Gene page
cholesterol a high fat diet 10% (2010)
airbourne pollution This causes cardiovascular disease, and will contribute to macular disease. In urban environments, ~8% of deaths are generally attributed to pollution BMJ 14
alcohol Excess alcohol is also related to ARMD, see 
sunlight Strong sunlight contributes to ARMD; and sunglasses protect, see.  But gentle sun exposure increases vitamin D production, and this will reduce the risk of many conditions such as diabetes, osteoporosis, and prostate cancer. Retina16
inflammation Chlamydia  high CRP, dental caries, each contribute
macular pigment Light skin increases risk Eye 2012.
obstructive sleep apnoea Untreated obstructive sleep apnea hinders response to bevacizumab in age-related macular degeneration  Retina 16     BJO 17
Oral Bisphosphonates AJO 16     2-4x risk
Choroid BJO 17


Other countries

pie chart illustrating factors contributing to ARMD



Some communities in Japan did not develop macular degeneration as people aged, but as soon as they started eating Western food the condition started to occur. Similarly, when Japanese people move to Western countries, they develop the condition more frequently.

These observations suggest that the high fat, and type of fats, such as saturated and trans-fats, the lack of protective fats (omega 3s, from fish), and salt (by increasing blood pressure) increases ARMD. Lack of exercise as we drive everywhere in Western countries will contribute.



We inherit these from our parents. Genes are the genetic information that tells our body what chemicals to make. Overall, our genes may contribute to more than 50% of ARMD. The main genes have been found. Gene page.   For example, these genes control the way used-up chemicals are removed from the eye. Being long-sighted (hyperopic) is also a risk factor


A healthy lifestyle

A healthy lifestyle helps to prevent age related macular degeneration. This is important for the younger relations of age related macular degeneration sufferers:



smoking increase the risk or ARMD 3-4 times


the risk of smoking and passive smoking and ARMD


  • Overall smoking accounts for 32% of ARMD. Even stopping at the age of 80 will reduce the risk of developing the disease. So if you have a relation with macular degeneration, try and stop as smoking may make it develop earlier.
  • Smoking increases the risk of macular degeneration about 3 times. Macular degeneration occurs 10 years earlier in smokers.
  • If you have macular degeneration, do try and stop. Even if you are 90 years old stopping smoking will help your eyes considerably.
  • Passive smoking is also harmful: for instance, if your partner smokes cigarettes a day, you receive 25% of the smoke, so that is equivalent to you smoking 5 cigarettes a day. 28000 cases a year in the UK. See 2002 report and 2003 study . Lithuania     Japanese    China   Ophth 20
  • Passive smoking doubles the risk  ,  personal smoking triples the risk of both geographic atrophy and neovascular ARMD.
  • Each cigarette increases the ARMD progression rate ~15%.


Blood Pressure & Exercise

dancing and all other forms of exercise delay ARMD


  • 30 minutes a day at least, walking, or more active exercise for younger people,  reduces risk by 70%: 2006
  • Exercise may help by preventing hardening of the arteries. 30 minutes walking a day (regular walking) three times a week will reduce ARMD risk by one third, compared to people who don't walk or exercise and who drive everywhere.
  • A low blood pressure helps. A level of 140/85 or below is likely to be best. Blood pressure is written as '140/85', with the systolic/diastolic. Above 115 (systolic) the risk of heart disease increases. See the evidence and more. Macular haemorrhages are more likely with high blood pressure. More evidence Eye.
  • Obesity is also a risk factor see. 
  • A low salt diet is important Salt and more than 2 units of alcohol a day may cause blood pressure to rise.



after 8 units of alocohol blood pressure rises for 2 days


Too much may contribute indirectly by increasing blood pressure, and is related to ARMD, see.

Blood pressure rises after drinking (opposite...drinking 4 pints/bottle of wine).

Each gram of alcohol puts systolic blood pressure up 0.24mmmHg, diastolic 0.16 mmHg. This means 1 pint of beer (2 units, each unit 8g alcohol) with 16gm of alcohol, drunk every day, will put the systolic blood pressure up (16 x 0.25=) 4mmHg.



Experts recommend a healthy diet.

fruit and a healthy diet will sigificantly reduces the risk of developing ARMD

7 portions of vegetables a day and 2 portins of fruit, with portions of different colours



Fruit/vegetables prevent 36-50% of ARMD see, see and see (fruit & vegetables lower homocysteine levels, and this improves blood flow) BMJ 15. Pulses like beans are fine. Bread, pasta, rice and potatoes provide 'energy'. Vegetarians have lower blood pressures and healthier lipid levels,  see . A healthy diet reduces homocysteine levels, which are associated with ARMD. Certainly saturated fats increase the risk of ARMD; and fish and polyunsaturated fats halve the risk. Avoiding certain fats helps, with strong evidence here (explained more clearly here for heart disease). Nuts may help prevent ARMD (small amounts...they are fattening).

Vitamin supplements

Age-Related Eye Disease Study--Results

Lutein and Zeoxanthin  supplements slow down progression on average 10%, AREDS 2, 20% if diet is poor.

2020 As the macula is the most chemically active area in the body, with the greatest oxygen demand, it has been thought that antioxidants such as vitamins may play a critical role. The retina contains the pigments carotenoids lutein, xeaxanthin, mesoxanthin.

Lutein is in dark green leaves such as kale and spinach, and most of us do not eat enough. Xeaxanthin is in orange peppers, corn, nectarines and oranges (and other yellow/orange fruits/vegetable). "Higher dietary intake of lutein/zeaxanthin was independently associated with decreased likelihood of having neovascular AMD, geographic atrophy, and large or extensive intermediate drusen" Seddon.  No need Cochrane 2017.



Oily fish

oily fishes reduces ARMD  ~40%

Oily fish twice a week reduces ARMD by 40%, especially oily fish such as tuna, mackerel, sardines, herring, and salmon. A Japanese diet may be helpful as above. Other omega 3 fats are helpful. See


Cholesterol & statins, patient and relatives


Statins benefit

no benefit

ARMD is commoner in people with higher cholesterol levels. Atherosclerosis, caused by a high cholesterol, does contribute to ARMD, see .  Statin treatment reduces macular degeneration. DK recommends them for people with ARMD.   Naturally all relatives of ARMD patients should address this issue of fat levels in the blood, sticking to a low fat diet with plenty of exercise, avoiding obesity, just as described on this page for ARMD patients. Statins may not help


Macular pigment

Macular pigment density is inversely related to ARMD: the thicker the pigment the less likely the condition.

  • this explains why the condition is much commoner in Caucasians with blond hair and lighter coloured retina
  • increasing the pigment with lutein may delay the condition Acta 2012  Eye 2012
  • ARMD is unusual in Afro-Caribbeans, and this may be because the 'elastin' layer is thicker.
  • Especially in wet ARMD with CNV, the elastin layer acts as a barrier to the growing CNV (new vessels). Elastin is part of Bruchs membrane link.


Cataract surgery and Vitreous changes


One paper suggests cataract surgery leads to an extra 4-5 times risk of developing neovascular macular changes or dry ARMD. Another states this is not so AREDS 25. Certainly patients with early ARMD undergoing cataract surgery should be warned of symptoms, that is distortion or changes in central vision, and attention should be sought in a few days. Also.

If the vitreous is separated from the macular the risk of CNV is significantly reduced AMJO 09.


Wet ARMD (exudative/leaky)


retinal damage

(vascular endothelial growth factor)

blood vessel growth

leakage..blood and fluid

give anti-VEGF drug

leakage stops for a while

In wet ARMD, new vessels grow under the central retina in the macular area, causing retinal leakage and swelling. (CNV..choroidal neovascularisation). The blood vessel growth seems to be part of the eye's 'healiing' response to ack of oxggen and damage. The damaged retina releases a chemical VEGF (Vascular endothelial growth factor). The VEGF stimulates blood vessel growth, to produce the different types of wet ARMD. In addition, the new blood vessels leak, causing fluid under the retina in these condition.

The network of blood vessels usually progresses to cause a scar in the macular area. If the scar is small, sight is reasonable; but if large, the sight can be very poor. It is very difficult to predict whose dry ARMD will progress, but the risk factors include those mentioned above (soft drusen, high blood pressure, smoking, poor diet, lack of exercise). This is described below.

There are different types of wet ARMD


'Occult', no PED, = Mixed (predominantly or minimally classic CNV with occult CNV) wet armd

type 1 CNV ('occult')

type 1 cnv

In this type of ARMD, there are new blood vessels, but they are not clearly seen with the angiogram. 'Occult' CNV is the term given to a specific 'blotchy' appearance of the angiogram. This is probably an early phase of classic, see . Occult and classic patterns can occur together. Anti-VEGF drugs generally help. The symptoms of this type of CNV are the same as 'classic CNV', except the condition takes longer to develop. Without treatment, this usually turns into classic CNV over the next months or years, to cause poor central vision.

  • Large CNV membranes can develop haemorrhages with anti-VEGF treatment (BJO 2008).
  • photo   another   another..occult/mixed    another   flash   another    large diagram
  • The term occult is not really used now: the condition is a subtype of wet armd sometimes termed type 1 cnv.
  • Sometimes there is a hyper-reflective material which is related to prognosis, and to pachychoroidopathy (= thickened choroid).
  • Sometimes there is fluid, but if the fluid is stable injections don't seem to help.

Mixed: classic CNV (formally termed 'classic CNV') wet armd


early cnv (macular degeneration)

New vessels growing under the central retina in a 'classic' pattern: Anti-VEGF treatment needed.  enlarge  Photo (case 12)


When blood vessels grow under the macula, this is termed choroidal neovascularisation (CNV). When the new vessels are seen easily on a fluorescein angiogram, they are called 'classic CNV': they look like a net of blood vessels.

When a doctor looks in the retina looks elevated, there may be tiny haemorrhages, a grey area, or exudates. Severe . In milder cases vision may still be good. The condition may develop over days or weeks, with increasing distortion or blurred central vision. If this process is early you can still read, but if it becomes severe reading with any magnifier is impossible. Treatment is based on anti-VEGF drugs,  although other treatment are available

This is usually a serious type of macular degeneration, serious because it can cause very poor central vision. It never blinds in the sense that you cannot see light and dark, but in its serious form it can damage the central vision so you can only see fingers or even the movements of hands. Once again, the side vision will normally be good, so you should always be able to walk around the house.

ARMD progression rate and relative risk of smoking geographic neovascular
active smoking x 3.4 x 2.5
passive smoking x 2


CNV vascularised PED =fibrovascular PED and serous PED with neovascularisation wet armd

In this type of CNV there is a PED (pigment epithelial detachment)



occult cnv with a PED (a type of macular degenerationa PED..pigment epithelial detachment, with CNV (choroidal neovascularisation): with a PED. This condition usually progresses, but progression rates are very variable.


In this type of wet ARMD the damaged area looks like a dome, but in addition fluid leaks under the retina, hence the term 'wet'.

Anti-VEGF drugs generally help. The PED may reduce in size with treatment, and treatment will reduce intraretinal and subretinal fluid. Retina 2011. Occasionally the retina may 'rip', causing more loss of sight Eye 2011. Overall, 15% of PEDs rip, but the risk is proportional to the PED size, so a large PED is much more likely to rip. About of 8% of patients may develop worse sight with treatment Retina 17. The rip typically occurs 2 months after starting treatment. The rip may not cause that much visual loss initially, but central vision may get worse over time.


a vascularised PED (a type of wet ARMD)

November, 7 months later, a PED has developed, with a retinal haemorrhage. Also, intraretinal and subretinal fluid.

Patient, age 86, April, reasonable vision 6/24 Photo / OCT show drusen, hard and soft enlarge


A wrinkled PED

This probably represents CNV without subretnal fluid, and needs treatment Retina18:

wrinkled PED




  • OCT changes Retina 20
  • treatment should focus on vision gains rather that PED resolution  Retina 18. We dont need to elimniate the PED to get the best results.
  • ARMD with a PED is classified as CNV, type 1.  Outcomes Eye 11
  • Look for polyps,    see   PCV.
  • photo  case 9 r/l     left     case.
  • There are 3 types of PED, reviewed here (avascular, occult, polypoidal). 
  • photo avascular PED
  • intraretinal cysts indicate a poorer response BJO14; combined with geographic atrophy BJO 14
  • treatment helps stabilize/improve SIO 15; fluid fluctuates with injections every 2 months;  serous PEDs respond better Retina 16; incomplete response to anti-vegf AJO 16    Variable response  Retina 17.  Good response Retina 18
  • Genetics Retina 20

Retinal angiomatous proliferation: 'RAP', type 3 CNV

type 1 cnv

type 3 CNV, a rap: the choroidal vessels and retinal vessels join up (anastamose)

A RAP (retinal angiomatous proliferation) is a type of wet ARMD. It does not respond as well to antiVEGF treatment as the other types.

  • text    multifocal Retina 20
  • 25% good response Retina17
  • mean timme of recurrence was 5 months after the 3rd injection Retina17
  • Eye 15
  • Retina 16 OCT  "subfoveal choroidal thickness <200 μm, presence of intraretinal fluid accumulation, absence of subretinal fluid, gently-sloping dome-shaped retinal pigment epithelial detachment or trapezoid-shaped retinal pigment epithelial detachment without an obvious peak, and intraretinal mass lesion"
  • beginning with    Retina15   "the earliest sign of Type 3 neovascularization is punctate hyperreflective foci above the external limiting membrane. The mature Type 3 lesions and associated serous pigment epithelial detachments are highly responsive to anti-vascular endothelial growth factor therapy"
  • During treatment 5% of patients developl submacular haemorhages, and 5% rips  Retina18

a dome is shown on the OCT...fluid, enlarge, and there is exudate and a small haemorrhage enlarge.



Polypoidal choroidal vasculopathy

This is another type of CNV. The condition is seen as a branching choroidal network of vessels with vascular dilatation.

  • Types Retina 19 "Typical polypoidal choroidal vasculopathy was defined as eyes with polypoidal changes to neovascular tissue, accompanied by increased choroidal thickness and/or the presence of pachyvessels, in the absence of drusen, characteristic pigmentary abnormalities, and geographic atrophy. Polypoidal choroidal neovascularization was defined as polypoidal changes to neovascular tissue that did not meet the definition of T-PCV as described above. Polyps in P-CNV typically represented only a small portion at the end of a much larger Type 1 neovascularization on ICGA."
  • Excellent review TAO 19
  • more common in Chinese and Afro-Caribbeans.
  • The choroidal neovascularisation often occurs with a serous haemorrhagic PED.  
  • Polypoidal choroidal vasculopathy page.   
  • multiple PEDS, subretinal haemorrhages, visible polyps: deep orange lesions
  • lipid exudates, subretinal fluid, RPE atrophy, peripapillary lesions
  • classic & occult cnv, peripheral lesions: Features see
  • distinguishing polypoidal choroidal vasculopathy from typical neovascular age-related macular degeneration based on spectral domain optical coherence tomography Retina16
  • Wilki
  • type 1 and type 2 IOVS; this depends on the presence or absence of feeder vessels Retina 18
  • CNV in PCV respond slightly better to Eyela, and intervals can be extended to 16 weeks (2019)


Other types of wet ARMD

Signs of activity on OCT

  • On OCTA there are more small vessel branching and peripheral arcades in active lesions Retina 18
  • hyper-reflective foci indicate progression
  • drusenoid PEDs indicate progression

hyper-reflective foci

hyper-reflective foci enlarge


drusenoid ped enlarge



  type 1 cnv type 2 cnv type 3 cnv polypoidal cnv
Mixed mainly occult CNV new vessels under the retinal pigment epithelium
Mixed mainly classic CNV, subretinal new vessels
Retinal angiomatous proliferation (RAP), intraretinal new vessels
polypoidal cnv
  labels for types of cnv    



Pigment epithelial detachments (PED), summary

PEDs are present in different types of ARMD, but the caues are slighty different. The treatment depends on the cause. The PED is a dome of fluid under the pigment layer of the retina.

Hereare the different types of PED, some of which were discussed above:


Serous (avascular) PED

This is another type of PED, without any vascular element. In younger patients this is usually part of Central  Serous Retinopathy. In older patients this is usually part of 'dry' ARMD, and there may have been obvious 'dry' changes visible before this develops. Anti-VEGF treatment is not helpful (Eye 2010). Perhaps a serous PED in an older patient is better thought of as half way between dry and wet ARMD.

However, if the other eye has had wet ARMD, then such an eye is at very high risk of wet ARMD itself. Eye 2012  . It is probably safer for such a patient to have regular OCT examinations, perhaps every 3 months: as yet there is no evidence to prove that this will help, but logically it will help by detecting very early disease that is much easier to treat.

The PED is a dome of fluid under the pigment layer of the retina. there is a 'PED' only, no leak

'PED', with a leak under the retina (shown here) or in the retina




Distortion of vision and other symptoms: dry ARMD changing into wet ARMD

How would you know if you have the 'neovascular' type of age related macular degeneration? Some symptoms suggest you may be developing the problem:

  • if one is is 'wet' , 3 monthly octs for fellow eye and home monitoring Retina 20
  • distortion of vision, where straight lines such as window frames appear bent as shown below
  • a feeling as though you are looking through water
  • distortion only occurs in 10-50% of patients
  • 7/8 patients have no symptoms in the early stages  BJO 2011
  • amsler helps with training Eye 2012, Eye14 ,
  • early detection CO14 , BJO 16

If you do develop distortion of vision you usually need to see your optometrist and have an OCT scan within a few days. See the amsler test below.  Your optmerist or ophthalmologist will recommend an OCT scan, and this shows the wet ARMD immediately.

Wet ARMD progresses 4 times faster (a 400% increase in progression rate) in smokers. Dry ARMD may develop into 'wet' ARMD (4%/year). In wet ARMD, leaks develop, and new vessels start to grow right through the retina. Occasionally wet ARMD develops without dry changes, although usually there is an area of retinal damage that triggers the process. photos  There may be a trigger factor such as inflammation, that triggers the conversion of dry to wet. (For example. teeth decay bacteria have been implicated.)


Amsler grid test

distortion of sight

Distortion of straight lines which may start to appear crooked over a few weeks usually means the ARMD is progressing. Sometimes this is due to the 'neovascular' ARMD developing, and you are advised to be checked in case laser may help.

Patients should be given the Amsler Grid test to use every day, or at least once a week, at home. These authors recommend this test, although personally I have found that patients may still present late (this is a major problem). Patients are given a grid, told to look at the central spot with their reading glasses on, using one eye at a time. If any of the adjacent lines become bent or wiggly or distorted, then CNV (blood vessels growing under the macula) may be present, and patients should see their optometrist, ophthalmologist (or in Birmingham attend the Eye Centre Casualty, City Hospital).  The test is explained well here . home device  another Ophth14

Unfortunately visual changes follow changes that can be detected by OCT scans BJO 2011  CNV are detected

  • 1/8 when the patient notices changes generally
  • 1/3 when there are changes in the amsler grid
  • 1/3 by reduced vision acuity reading a chart as compared with OCT. Monthly OCTs are necessary to detect recurrences!
  • late presentation is common and linked to social deprivation BJO14
  • a home device may be best Eye 16  see


ARMD and the other eye, risks

Unfortunately age related macular degeneration can affect the other eye. See healthy lifestyle above: this may help. If you do notice a change in your sight, see distortion above. Risk from drusen

  • The atrophic or dry type usually does occur in both eyes, but remember this generally gets only worse slowly.
  • There may be a gap of years before the process begins in the second eye.
  • If one eye has had wet ARMD, and the other eye has a PED, then screening with regular OCTs may help.
  • If you notice the symptoms (central vision becoming distorted or blurred, sometimes like looking through water) you should have your eye checked with an OCT scan: see distortion.

Concerning neovascular or wet type ARMD:

  • The neovascular or wet type can also affect the other eye, at an overall rate of ~50% over the next 5 years. BJO 17
  • High blood pressure, one large drusen near the fovea, 5 drusen in the macular area, and retinal pigment epithelial changes each contribute to this 90%.
  • So if you have only one of these risk factors, such as 5 drusen and a low blood pressure and don't smoke, then the progression rate is about 23% over a 5 year period . If you have 2 risk factors, 45%.
  • But if you have 2 risk factors (45% 5 year risk) and your partner smokes 20/day, your risk is 45 x2 = 90% over 5 years...see immediately below.
  • The figure is 4 times higher for smokers, and twice as high for passive smokers. (If smoking at 20 cigarettes/day.)
  • the active phase may last 3-12 months, with the sight deteriorating during this time, and after that they may be little change. Treatment (laser & drugs) is needed during the active phase, and is of no help later. Anti-VEGF treatment may be needed for 2 years.

Aspirin and anticoagulants

  • aspirin and anticoagulants can lead to more bleeding from wet AMD
  • but their benefits usually outweigh the risks
  • Primary prevention: risks and benefits. In patients who, under current guidelines, are eligible for treatment because of their 10-year risk of myocardial infarction or stroke, "the presence or absence of strong risk factors for neovascular AMD might tilt treatment decisions in one direction or the other."


Some other features of ARMD


macular scar diagram ARMDScarring in ARMD

Many types of macular degeneration progress to cause scarring. 'Dry' types usually progress more slowly, but occasionally can cause very poor central vision, but this is commoner in the 'wet types'.

If your conditions is severe wet scarring is likely.


Rip / tear

Sometimes retina in the macula area can tear and shrink. This is call a 'rip' or a 'tear' of the pigment epithelium. It may occur spontaneously as part of wet ARMD, but can occur after PDT or anti-VEGF treatment, particularly if there is a large PED. A rip may cause significant loss of central vision see. but the risks are only slightly increased.

The chances of rip depend on how elevated the PED is (the retinal pigment epithelial detachment). For instance, an 840μ elevation has a 50% chance of ripping. A 500μ elevation has a 10% chance of ripping. Gelsiken 2009   A Case.   Rip: separate page for printing.



Here is a summary of some of the abbreviations ophthalmologists use in this condition:

anti-VEGF / injection drugs that reduce growth and leaking from the new blood vessels under the retina in ARMD, or on the retina in diabetes etc. They are given by injection into the eye. Avastin, Lucentis, Eyela.
ARM age-related macular disease = age-related macular degeneration = ARMD
ARMD age-related macular degeneration
Classic CNV easy-to-see neovascular ARMD    (based on angiogram) blood vessels growing under the retina and leaking
CNV choroidal new vessels (i.e. neovascular macular degeneration, or 'wet'). Blood vessels growing through the retina under the macula. Also called CCNV.
CNVM or CNVm a choroidal neovascular membrane, that is a network of CNV, although in practice this means the same thing as CNV
CSR central serous chorio-retinopathy
drusen a type of aging change of the retina...tiny white spots/areas
dry ARMD thinning (and other changes) of the central retina
FFA fluorescein angiography
Fovea the very centre of the macula
GP general practitioner
ICG indocyanine green angiography
IRF, irf intraretinal fluid (an OCT scan finding)
macula the centre of the retina that sees detailed vision like faces and reading
neovascularisation similar meaning to wet armd
NSD, nsd Neurosensory detachment
OCT / scans optical coherence tomogram: a 3 dimensional photograph of the macula, called a scan
Occult CNV hard-to-see neovascular ARMD (based on angiogram) blood vessels growing under the retina and leaking (but the leakage is late) (type 1 CNV)
PCV Polypoidal choroidal vasculopathy
PDT photodynamic therapy (for classic sub-foveal neovascular ARMD )   
PED pigment epithelial detachment, a type of wet ARMD
RAP, rap retinal angiomatous proliferation (type 3 cnv)
Rip a pigment epithelial rip or tear
SRF subretinal fluid (not subretinal fibrosis)
Subretinal fluid fluid under the retina typically type 2 cnv (or part of other types)
VEGF Vascular endothelial growth factor...the main chemical that makes blood vessels grow in ARMD
VMC Virtual macular clinic..patients attend for an OCT and the scan is interpreted later, and the patient contact if another anti-vegf injection is needed
wet (armd) wet age-related macular degeneration, with CNV as above (blood vessels growing and leaking under the retina, usually under the macula)




support, USA Macula Degeneration Support Website
animation   (helpful)
more facts, UK Royal National Institute for the Blind
support, UK 

The Macular Society
PO Box 1870
Andover SP10 9AD
Tel: 0300 30 30 111

ARMD web site
depression this is common and can be prevented/treated   See our LVA page
thanks to Photos thanks to Good Hope and BMEC photographers/staff